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br O GlcNAcase Human OGA
2019-08-09
O-GlcNAcase Human OGA is a multidomain protein with an N-terminal domain similar to glycoside hydrolase family 84 (GH84) enzymes, a stalk domain, a C-terminal pseudo histone acetyltransferase (HAT) domain, and several low-complexity regions (Figure 1f) [43]. A splice variant that lacks the HAT do
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br Conclusion The past few years have
2019-08-09
Conclusion The past few years have witnessed substantial progress in understanding the structural mechanisms of substrate recognition and the reactions catalyzed by the O-GlcNAc-cycling enzymes, but more work remains. In particular, future research will be needed to establish how OGT and OGA inte
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br Materials and methods br Result and discussion qRT PCR
2019-08-09
Materials and methods Result and discussion qRT-PCR was utilized to explore the effect of acetamizuril on the mRNA level of enolase. The results were analyzed according to the Livak 2−ΔΔCT method (Schmittgen and Livak, 2008): the mean CT of the enolase in treated and untreated samples was 29.8
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PQ 401 The E enzyme is the apex for downstream enzymatic
2019-08-09
The E1 enzyme is the apex for downstream enzymatic cascades and signaling pathways mediated by Ub and Ub-like proteins (Ubls) (Pickart, 2001). Studying characteristics of E1 and its catalytic functions may throw light to the role of ubiquitination in cell development. All known eukaryotic E1 are mon
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Magnified regions of the upregulated proteins identified by
2019-08-08
Magnified regions of the upregulated proteins identified by MALDI-TOF are shown in Fig. 2. The identified proteins were phosphoglycerate kinase, fructose-bisphosphate aldolase class II, alcohol dehydrogenase, phosphoglyceromutase, 6-phosphogluconolactonase, malate dehydrogenase, alkyl hydroperoxide
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In the present study we did not examine whether
2019-08-08
In the present study, we did not examine whether the CpG site-specific COMT methylation are associated with any genetic variants in response to E2, GEN or SFN. Some studies suggest that oxidative DNA damage causes genetic variation which may induce epigenetic changes that lead to gene silencing (Kho
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In the intestine absorbed cholesterol
2019-08-08
In the intestine, absorbed cholesterol can either be esterified by ACAT2 (Soat2) and packed into chylomicrons, transported back to the intestinal lumen by ABCG5/ABCG8, or it can be transported into HDL by ABCA1. ACAT2 is confined to enterocytes and hepatocytes and esterifies cholesterol for intracel
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In contrast to AChE BuChE Table exhibited
2019-08-08
In contrast to AChE, BuChE (Table 2) exhibited a measurable time-dependent inactivation only with Trelagliptin 2 among the four acetophenones in this study. Values of Ki obtained from steady-state inhibition of BuChE by all four acetophenones were, as noted in the Results, 10- to 200-fold greater (
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All these results indicate that cleaving
2019-08-08
All these results indicate that cleaving embryos possess a regulative mechanism, sensing the number of inner Sal 003 and controlling the proportion of conservative and differentiative divisions of blastomeres. The current observations agree with the results from other laboratories and our previous
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Introduction Ewing sarcomas primitive neuroectodermal tumors
2019-08-08
Introduction Ewing sarcomas/primitive neuroectodermal tumors (ES/PNETs) are relatively infrequent but the second most common sarcoma of the bone next to osteosarcoma. Nearly 80% of them occur in persons younger than 20years. Most of them arise from the bone, but 10 to 20% of them from soft tissue.
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Herein we further established a dynamic DNA
2019-08-08
Herein, we further established a dynamic DNA self-assembly activated hemin-mimetic enzymes system by embedding DNA-hemin into an entropy-driven DNA-assembly for fluorescent biosensing. The entropy-driven dynamic DNA-assembly is one of the toehold-mediated isothermal strand displacement reactions, wh
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In principle in vitro techniques for assessing
2019-08-07
In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized Toosendanin lines (such as those derived from hepatomas) and reporter gene constructs
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Dgat−/− mice however had less adipose
2019-08-06
Dgat−/− mice, however, had less adipose tissue, as reflected by lower total fat pad weights and body triglyceride content.
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In addition to PGC1α
2019-08-05
In addition to PGC1α, transcriptional co-repressors such as NCOR and RIP140 participate in oxidative muscle remodeling induced by exercise, whereby reductions in their expression and the resulting de-repression of downstream TFs activates oxidative gene expression (Seth et al., 2007, Yamamoto et al., 2011, Fan et al., 2013).
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Recently, a sandwich-cultured hepatocyte model
2019-08-02
Recently, a sandwich-cultured hepatocyte model has been proved to be a valuable in vitro system that maintains specific hepatic cytomorphology and function relevant to drug metabolism, disposition and toxicity, and thus, closely resembles the in vivo setting.
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