• ROS generation is crucial for NETs release

  2021-02-23

  

  ROS generation is crucial for NETs release upon both physiological or pathogenic stimuli [16,30]. In our study, we further verified this conclusion by demonstrating that SRA stimulation by Poly I enhanced intracellular ROS levels while scavenging of ROS by anti-oxidant agents effectively abolished t

• The interferences between thapsigargin and forskolin

  2021-02-23

  

  The interferences between thapsigargin- and forskolin-induced Ca release indicate that these drugs deplete the same intracellular stores in RASMC. In fact, after partial depletion of thapsigargin-sensitive stores, the forskolin-induced increases in [Ca]c were significantly reduced. Similarly, a prev

• Key molecules in the EP second messenger signaling cascade t

  2021-02-23

  

  Key molecules in the EP1 second messenger signaling cascade that are necessary for potentiation of GluK2/GluK5 were identified. We also identified three GluK5 serines located in a membrane-proximal C-terminal domain that, when mutated to the phosphomimetic aspartate and expressed with GluK2, rendere

• Because of the lack of sequence current

  2021-02-23

  

  Because of the lack of sequence, current knowledge on the cellular regulation of CoA-IT is scarce. However, recent work has suggested an interesting new role for CoA-IT in regulating the extent of the AA mobilization response in primed macrophages. Bacterial lipopolysaccharide (LPS) is a poor trigge

• Although DP technologies are convenient for users

  2021-02-23

  

  Although 3DP technologies are convenient for users to manufacture devices automatically, the printing materials are inevitably limited by the manufacturers of 3D printers. Strategies are increasingly being developed to functionalize the raw printing materials or their printed devices with other phys

• br Introduction Mammalian proteases comprise both the

  2021-02-23

  

  Introduction Mammalian proteases comprise both the peptidases or exopeptidases, which act at the N- or C-terminal positions of polypeptides, and proteinases or endopeptidases, which are capable of cleaving peptide bonds in the central regions of polypeptides. The endopeptidases are classified in

• The molecular mechanisms regulating the differentiation of T

  2021-02-23

  

  The molecular mechanisms regulating the differentiation of Th1 versus Tfh Cathepsin K Activity Fluorometric Assay Kit from IL-12-stimulated CD4+ T cells remain largely uncharacterized in humans. This topic has been extensively studied in mice (Weinmann, 2014), because IL-12 stimulation promotes mo

• br Experimental Procedures br Acknowledgments

  2021-02-23

  

  Experimental Procedures Acknowledgments We thank R. Brink for providing HEL2x, M. Tanaka for CD169DTR mice, R. Lathe for making Cyp7b1+/− mice available, and M. Barnes and A. Reboldi for comments on the manuscript. T.Y. is an Irvington Institute Postdoctoral Fellow at the Cancer Research Insti

• The first purpose of the

  2021-02-23

  

  The first purpose of the current study was to characterize a standardized experimental model of postprandial hyperlipidemia in various rodent species. To our knowledge this study provides the most comprehensive and systematic evaluation of rodent models of postprandial hyperlipidemia to date. We ada

• CIC mediated chemoresistance is driven by several

  2021-02-22

  

  CIC-mediated chemoresistance is driven by several factors. In our quest to learn about these, we examined the crucial mediators identified earlier in the regulation of CSC survival and chemoresistance, such as BCL2, cleaved Caspase-3, COX-2, and macrophages. Interestingly, we observed a significantl

• Recently it was reported that Crm is linked

  2021-02-22

  

  Recently, it was reported that Crm1 is linked to spindle pole body (SPB) by Spc72 in a good thing yeast [9]. Spc72 and Spc110 are two specific receptors of γ-tubulin complex (Tub4), which target Tub4 to SPB and mediate the nucleation of microtubules from SPB [20]. It was found that disrupting the i

• Although intact Chk is distributed throughout the

  2021-02-22

  

  Although intact Chk is distributed throughout the nucleus and the cytoplasm (Fig. 1), the deletion of the SH2 domain greatly augments nuclear localization of Chk. The SH2 domain-deleted mutants might lose the ability to localize to the exterior of the nucleus due to a lack of the binding to a hypoth

• Endothelins ETs are peptides expressed in both the periphera

  2021-02-22

  

  Endothelins (ETs) are peptides expressed in both the peripheral and the central nervous systems, which can contribute to sensory changes seen in animal models of inflammatory, cancer and neuropathic pain [10], [11]. All three mammalian isoforms (ET-1, ET-2 and ET-3) activate specific G protein-coup

• Astrocytes play a key role in the brain as

  2021-02-22

  

  Astrocytes play a key role in the brain, as these cells are involved in fluid, ion, pH, and neurotransmitter homeostasis, synapse function, energy and metabolism and blood-brain barrier (BBB) maintenance (Sofroniew and Vinters, 2010). PA is able to activate different damaging responses in astrocytes

• br Experimental br Results and discussion

  2021-02-22

  

  Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it PHA-665752 is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the conversi

14746 records 695/984 page Previous Next First page 上5页 691692693694695 下5页 Last page