• Introduction Glaucoma consists of a group

  2024-11-08

  

  Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion gssg and damage of the optical nerve. It is well accepted that a critical risk

• Adiponectin is an adipokine whose circulating level is deple

  2024-11-08

  

  Adiponectin is an adipokine whose circulating level is depleted in a number of metabolic diseases including insulin resistance, diabetes and cancer (Khan et al., 2015, Singh et al., 2014a, Singh et al., 2014b, Yamauchi et al., 2014). Despite its importance in health and pathophysiology, adiponectin

• omacetaxine We aim to evaluate the AK in

  2024-11-08

  

  We aim to evaluate the AK in regulating adenosine signaling in the retina. It was reported that the degree of omacetaxine injury directly depends on expression levels of AK and the resulting extracellular levels of adenosine (Boison, 2006). Indeed, transgenic mice overexpressing AK are highly suscep

• Phenacetin br Actin cytoskeleton in protrusion

  2024-11-08

  

  Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing Phenacetin filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lame

• All consecutive patients who were confirmatively diagnosed w

  2024-11-08

  

  All consecutive patients who were confirmatively diagnosed with MP-PPE and TPE, respectively, between January 2008 and December 2016 at Kyungpook National University Hospital, a tertiary referral hospital in South Korea, an area with an intermediate prevalence of active tuberculosis, were enrolled.

• br Introduction Adenosine deaminase ADA also known as adenos

  2024-11-08

  

  Introduction Adenosine deaminase (ADA), also known as adenosine aminohydrolase, is a key enzyme involved in the purine metabolism that converts adenosine to inosine irreversibly (Lupidi et al., 1997). It is a zinc containing metalloenzyme present in both prokaryotes and eukaryotes. In humans ADA

• To understand the kinase selectivity profile of this series

  2024-11-08

  

  To understand the kinase selectivity profile of this series, Gastrodin , as a representative analog from this series, was profiled against 216 purified protein kinases representing the tyrosine and serine/threonine kinase families using an in-house Caliper EZ Reader mobility shift assay. Assays wer

• br In our experience br History of

  2024-11-08

  

  In our experience History of ER and ACh tests As shown in Table 1, Stein et al. first reported the usefulness of intravenous injection of ER in diagnosing coronary insufficiency in 1949 [16]. In 1972, the first ER spasm provocation test was employed at the Cleveland Clinic during cardiac cathe

• The major strength of this

  2024-11-08

  

  The major strength of this study is the large sample size which increases the statistical power to detect the likely subtle differences in peripheral methylation observed in psychiatric disorders (Olsson et al., 2010). Larger studies help provide more robust estimates of true associations, as small

• In addition to pH regulation by

  2024-11-07

  

  In addition to pH regulation by ion (counter-) fluxes, acidification is regulated by the abundance of V-ATPase on organelles, by the pumping activity of the complex and by proton leakage. In yeast, the V-ATPase VO subunit a is the only subunit expressed in two isoforms termed Stv1p and Vph1p. V-ATPa

• In this study we found that ACL silencing is

  2024-11-07

  

  In this study, we found that ACL silencing is sufficient to impair myoblast differentiation and that this effect is accompanied by a decrease in MYOD early in the myogenic process and by a subsequent decline in fast MyHC protein Cy3 azide at a later stage of differentiation (Figure 4J). Furthermore,

• Cerebral ischemia occurs following the occlusion of

  2024-11-07

  

  Cerebral ischemia occurs following the occlusion of a cerebral artery by a thrombus and causes cell swelling due to cytotoxic edema and BBB disruption with vasogenic edema (Loreto and Reggio, 2010, Nakaji et al., 2006, Shibata et al., 2004). Vasogenic edema is directly linked to alteration of the BB

• Chlorogenic acid an abundant polyphenol found in coffee and

  2024-11-07

  

  Chlorogenic Salicylic acid (7), an abundant polyphenol found in coffee and the human diet, has various biological activities including antioxidant and anticancer effects [54]. Jiang et al. reported that compound 7 had a selective cytotoxic activity on human oral tumor cells (HSG, HSC-2) as compared

• br Results br Discussion br STAR

  2024-11-07

  

  Results Discussion STAR★Methods Author Contributions Acknowledgments We thank Angela Walker for assistance with the manuscript; Junlin Liu, Xiangxiang Gu, Na Chen, Lu Xue, and the BV Core Facility of iHuman Institute for their support; scientists and colleagues at Amgen Inc., Zhulun W

• Since the beginning of s more

  2024-11-07

  

  Since the beginning of 1990s, more than 17,000 papers about physiological relevance of antioxidants have been published according to data from web of science. Based on the available literature, it seems that assessing the antioxidant potential of food by means of in vitro assays or solely epidemiolo

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