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Elevated expression of Aurora A and B frequently
2023-04-20
Elevated expression of Aurora-A and -B frequently detected in a wide variety of human cancers strongly indicate that high expression of these kinases play roles in the development of cancer associated phenotypes. While Aurora-A has been shown to function as an oncogene when over expressed in mammali
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br Breast cancer The interactions
2023-04-20
Breast cancer The interactions between 15-LOX and COX enzymes also affect the outcome of breast cancer. Indomethacin, a COX-1 and COX-2 inhibitor, decreased the growth of human breast cancer (BC) cells in nude mice, as well as slowed the rate of lung metastasis formation [41]. The levels of 12-HE
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br Materials and methods br Results Dried leaves used were
2023-04-20
Materials and methods Results Dried ritanserin used were 48.46 g C. benghalensis, 857.98 g T. zebrina and 25.09 g T. fluminensis. The samples gave 12.9% C. benghalensis, 0.078% T. zebrina and 3.06% T. fluminensis methanol extracts. The methanol extracts were evaluated for their lipoxygenase i
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Two major categories of arginase
2023-04-20
Two major categories of arginase inhibitors have been distinguished (Fig. 3): the first category comprises synthetic arginase inhibitors, which have been developed from the substrate l-arginine [35]; and the second category includes inhibitors derived from natural products [36]. The category of synt
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br Introduction Active oxygen radicals in the human body hav
2023-04-20
Introduction Active oxygen radicals in the human body have a strong effect of inducing lipid peroxidation, which in turn induces oxidative imbalance and causes various diseases. Natural polysaccharides are substances with certain antioxidant activity. They are used as antioxidants and have advant
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The radiographic correlate will be similarly important for t
2023-04-20
The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary desogestrel synthesis neoplasms. It has been reported that icotinib and gefitinib, epidermal growth fact
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Metaphit australia The renin angiotensin system RAS is a hor
2023-04-20
The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid Metaphit australia [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) an
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While there is much in vivo work on prion
2023-04-20
While there is much in vivo work on prion-like Aβ, it has not been shown that one can induce inclusions of Aβ in cultured cells as has been shown for tau and α-synuclein. One reason is practical; Aβ is a low molecular weight metabolite cleaved from within the larger amyloid precursor protein (APP) a
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To elucidate this relationship we
2023-04-20
To elucidate this relationship, we developed a spatial model of Ca-influx through N-methyl-D-aspartate receptor (NMDAR), CaMKII/PP1 activation, and AMPAR insertion in a realistic spine geometry. Using this model, we show that i) variables in membrane voltage mediated Ca-influx, particularly the numb
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br Introduction Nonalcoholic fatty liver disease NAFLD is
2023-04-20
Introduction Nonalcoholic fatty liver disease (NAFLD) is a clinicopathologic spectrum of liver pathologies associated with excessive accumulation of fat in the liver. This spectrum is continuous but can be graded based on pathological features; in increasing severity, these are: bland steatosis,
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It has been largely demonstrated that several clinico pathol
2023-04-20
It has been largely demonstrated that several clinico-pathological factors influence ovarian cancer patients' prognosis, including residual tumor at primary cytoreductive surgery, FIGO stage, tumor grading, cancer histology and performance status [3,4]. Nevertheless, the recent awareness achieved in
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A decrease in lactate concentration in the incubation medium
2023-04-19
A decrease in lactate concentration in the incubation medium was observed in samples treated with heparin and 2′,5′-dideoxyadenosine compared with the control (0.05; Fig. 2B). Discussion In the present study we compared the oxidative metabolism and intracellular signals of heparin, the glycosami
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Despite these efforts to prevent oxidative metabolic degrada
2023-04-19
Despite these efforts to prevent oxidative metabolic degradation, and showed only marginal improvements in metabolic stability and still exhibited high plasma clearances as shown in . High molecular weight as well as relative high log values could be contributing factors to the poor PK profiles of a
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A rational approach for the design of
2023-04-19
A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a
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CYP A is one of the key metabolizing enzymes of
2023-04-19
CYP3A4 is one of the key metabolizing Thiomyristoyl mg of the cytochrome P450 (CYP) superfamily of heme-containing monooxygenases. As the CYP family of enzymes plays important roles not only in the xenobiotic metabolism and detoxification of a large number of drugs, but also in the biosynthesis of
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