The BDNF Val66Met polymorphism

2019-07-13

The BDNF Val66Met polymorphism is also associated with decreased dendritic arborization and impaired long-term potentiation [25]. This is particularly important for the hippocampus, and healthy individuals with a BDNF Val66Met allele have decreased hippocampal volumes [30]. Hippocampal atrophy is common in epilepsy [31] and is observed in individuals exposed to significant prolonged stress [32], which is a model for depression.

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2018-07-29